POS1553 THE SIGNIFICANT ASSOCIATION OF HLA-A26 WITH UVEITIS AND GASTROINTESTINAL INVOLVEMENT IN PATIENTS WITH BEHÇET’S DISEASE IN A MULTICENTER STUDY

Background Specific haplotypes of human leukocyte antigen (HLA) are associated with susceptibility and disease activity Behçet’s (BD). However, the clinical importance HLA-A26 in BD is not well recognized compared to that HLA-B51. Objectives This study aimed examine association between HLA-A26, HLA-B51, manifestations, severity BD, especially focusing on possession. Methods was a multicenter cross-sectional observational patients were enrolled from 2006 2021. All met International Criteria for [1] or diagnostic criteria Disease Research Committee Japan [2]. evaluated using Krause score reflecting entire spectrum manifestations [3]. Both serotypes genotypes accepted HLA typing. Results In total, 200 this study. Uveitis observed 95/196 (48.5%) gastrointestinal involvement 57/167 (34.1%). identified HLA-B51 (n = 52/106, 49.1%), 25/88, 28.4%), both 6/88, 6.8%). While showed no significant without adjustment possession higher frequency uveitis (HLA-A26 positive vs. negative: n 6/6, 100% 16/32, 50.0%, respectively, p 0.03) scores (median: 7 5, 0.02) under conditions Furthermore, influenced by HLA-A26: 5/9, 55.6% 0/21, 0%, 0.001), as 5/11, 45.5% 0/24, 0.001). 5 had 5/21, 23.8% 0/58, Conclusion coexistence involvement. suggested confirming HLA-A haplotype BD. References [1]J Eur Acad Dermatol Venereol. 2014; 28(3): 338-47. [2]Y Mizushima, G Inaba, Y Mimura. Report Committee, Japan; 1987. 8-17. [3]I Krause, et al. J Rheumatol. 2001; 28(5): 1033-6. Table 1. Comparison characteristics Total 88) (+) 38) 40) Gastrointestinal 30) Uveitis†, % 56.0 41.3, 0.24 100 50.0, 0.03 - 55.6 0, 0.001 involvement†, 42.9 36.2, 0.61 60.0 24.1, 0.14 45.5 + 23.8 0.002 score¶, mean 6 0.43 0.02 6, 0.27 6.5 0.04 †: (%) negative (%); Fisher’s exact test ¶: negative; Mann-Whitney U Figure Association Acknowledgements: NIL. Disclosure Interests None Declared.